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Chunk #24 — Results — Searches for chromosomal regions identified by clustered SNPs with nominally-significant case vs control differences in both European-American samples

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Genomic regions identified by overlapping clusters of nominally-positive SNPs from genome-wide studies of alcohol and illegal substance dependence.
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In addition, none of 3,000 permutation trials provides data that identifies as many chromosomal regions from permutated data as those identified by the real datasets. Thus, the null hypothesis that the chromosomal regions identified by both samples are identified based only on stochastic grounds also nullified by permutation testing data. The genes that: a) lie in chromosomal regions identified by data from both European-American samples and b) display the most nominally-significant SNPs are listed in Table 1; the complete list of chromosomal regions identified in this way is listed in Table S1. The fraction of the genome occupied by these results is 210% of the size expected by chance, based on the fractions of the genome occupied by clustered nominally positive results from each of these two European-American samples (data not shown).