Only individuals who reported drinking at least once per month for 6 months or more at any evaluation (regular drinking) were included in the analysis. Subjects who were 15 years or older and met DSM-IV criteria at any evaluation were classified as AD (n=687), and individuals who were 23 years or older and did not meet criteria for DSM-IV AD were classified as unaffected (n=773). All other individuals were classified as unknown (n=326), including self-reported AD children at a very early age (< 15 years) and unaffected individuals who were younger than 23 years old and thus had not fully passed through the primary age of risk for AD and therefore might still develop it. These 326 individuals were included in analyses of all other phenotypes.
