Several genes that showed association in single SNP meta-analysis were also found to be significant in gene-based association tests (Supplementary table 3). The test confirmed that multiple SNPs in a gene support the evidence of single SNP association analysis. Exocyst complex component 5 (EXOC5) on chromosome 14 and solute carrier family 26 member 4 (SLC26A4) on chromosome 7 were among the top genes identified in both gene-based and single SNP association analysis (p < 5 × 10−5). LMO1 (p = 0.01) and PLCL1 (p = 4.13 × 10−4) also showed nominal significance in gene-based analysis.
