NMDAR activation mediates the phosphorylation of downstream molecules such as ERK1/2 and PI3-kinase is a central mediator of NMDAR signaling to Erk1/2 (Perkinton et al., 2002; Crossthwaite et al., 2004). However, the lack of effect of inhibitors of MAPK and PI3-kinase on the ethanol-induced suppression of γ oscillations, suggests these kinases are not involved in ethanol-induced suppression of γ, which may be explained by an inhibition of ionotropic NMDAR function.
