Genes that harbor de novo protein disrupting variation in developmental disorders (DD) were obtained from the Deciphering Developmental Disorders Study (93 DD risk genes with genome-wide significance)64. We also obtained 102 ASD risk genes (rare variation burden, FDR<0.1) from the Autism Sequencing Consortium (ASC) study65. Schizophrenia risk genes with elevated burden of rare variation were obtained from Singh et al., 201666 (110 genes with FDR<0.3). Differentially expressed genes (DEG) in postmortem brains with psychiatric disorders were obtained from Gandal et al., 201840 (FDR<0.05). Cell-type specific DEG in AD postmortem brains was obtained from Mathys et al., 201924.
