in an organism [Ho and Crabtree, 2010]. Illustrative for these global effects of deregulating BAF-mediated chromatin remodeling is that mutations in six components of the neuronal BAF (nBAF) complex (SMARCB1, SMARCA4, SMARCA2, SMARCE1, ARID1A, and ARID1B) have been reported to cause distinct, albeit overlapping, syndromic ID disorders [Santen et al., 2013]. These conditions are now commonly referred to as the “SWI/SNF-related ID syndromes” [Kosho et al., 2013].
