adding new dentate neuronal progenitors to hippocampi rendered dysfunctional by regionally-restricted pathologies (Yu et al., 2014b). These may include such conditions as mesial temporal sclerosis or ischemic neuronal loss following hippocampal hypoperfusion, as may occur following cardiac arrest with prolonged resuscitation. While dentate neuronal replacement would not be so suitable for the memory loss of Alzheimer’s or Lewy body disease, which are both multicentric and preferentially involve the hippocampal pyramidal population, this strategy might well prove beneficial for treating the focal hippocampal injuries that follow ischemia and prolonged seizures.
