Figure 3b shows association results for all gene-tissue pairs with the height phenotype. We find that most associations fall in the gray, “undetermined,” region. When we restrict the plot to S-PrediXcan Bonferroni-significant genes (Fig. 3c), three distinct peaks emerge in the high P4 region (P4 > 0.5, “colocalized signals”), high P3 region (P3 > 0.5, “independent signals” or “non-colocalized signals”), and “undetermined” region. Moreover, when genes with low prediction performance are excluded (Supplementary Fig. 6d) the “undetermined” peak significantly diminishes.
