Significant reward network connections are illustrated in Figure 7. Among the 12 significant connections, nine were hypoconnected and three were hyperconnected in AUD individuals, involving 17 regions (7 from the left and 10 from the right hemisphere) of the 34 reward network ROIs. While the majority of these nodes (12 of 17) were of solo paths, connecting to another single node (ROI # 2, 3, 6, 7, 8, 14, 16, 19, 23, 26, 31, 34), two of them (ROI # 13, 20) were linked with three connections each, and three of them (ROI # 9, 12, 24) had two connections each. Out of nine hypoconnected FC variables, three were cortico-cortical connections (R.Ins–R.ACC, R.ACC–R.OFC, and R.ACC–R.PCC), involving only the right hemisphere, and five were subcortical–subcortical connections (R.Amg–L.Hip, L.Cdt–R.Pal, L.Tha–R.Tha, L.Cdt–L.Tha, and L.Tha–R.Ptm) involving both hemispheres, and one inter-hemispheric subcortical–cortical connection (R.VTA–L.ACC). Interestingly, all three hyperconnected FC variables were subcortical–cortical connections, involving a left-hemispheric connection (L.NAc–L.PCC), a right-hemispheric connection (R.Pal–R.PCC), and an inter-hemispheric connection (R.Hip–L.DLP).
