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Chunk #40 — Discussion

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Mechanisms in the relation between GABRA2 and adolescent externalizing problems.
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However, our results and those of previous studies collectively suggest that GABRA2 is implicated in several distinct facets of disinhibition. Taken together, perhaps GABRA2 variation predisposes adolescents to broad disinhibition, rather than to one specific facet. In addition, previous research suggests that common genetic influences underlie the association between impulsivity and sensation seeking [63]. Based on our results and those of previous studies, it is possible that this GABRA2 polymorphism or other polymorphisms in high LD might contribute to this common genetic basis.