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Chunk #7 — Materials and Methods — Study subjects — Parental Diagnoses

Source
Variants located upstream of CHRNB4 on chromosome 15q25.1 are associated with age at onset of daily smoking and habitual smoking.
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Parental diagnoses were constructed from each parent's structured set of assessments. This set of assessments consisted of all available direct interviews. However, if there were no direct interviews available, then the sequential set of family-history assessments specific to that parent were substituted. The criteria for each of the ever/never measures were examined on each of the assessments in turn, independently of any other assessment. Once the criteria for a given measure were met, then variable was coded as present and the corresponding AAO variable was set to the age reported.