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Chunk #27 — Results — PPI analyses

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Initial evidence that OPRM1 genotype moderates ventral and dorsal striatum functional connectivity during alcohol cues.
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versus A-allele homozygotes contrast (parameter estimates for the cluster: G carriers = −0.271, A homozygotes = 0.012; for PPI activation maps for each genotype group see supplementary materials). Specifically, G-allele carriers exhibited stronger negative correlations between the right ventral striatum and the insula, frontal medial cortex, superior parietal lobule, thalamus, putamen, and paracingulate gyrus as compared to A-allele homozygotes (Table 4, Figure 7). G-allele carriers were also found to have stronger negative correlations between the right dorsal striatum (caudate) seed region and the insula, orbitofrontal cortex, paracingulate gyrus, and subcallosal cortex (Table 4, Figure 8). Analyses using the left ventral striatum as the seed revealed the same pattern of results, with the exception of the temporal and lateral occipital areas.