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Chunk #35 — Methods — Part 2. Polygenic score properties for worldwide populations

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Analysis of polygenic risk score usage and performance in diverse human populations.
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risk scores for height and height phenotypes for three reasons: Four populations were excluded due to lack of height phenotype data: Puerto Rican in Puerto Rico (PUR; N = 105), Bengali in Bangladesh (BEB; N = 86), Punjabi in Lahore, Pakistan (PJL; N = 96), Mende in Sierra Leone (MSL; N = 85). Two populations were excluded due to the combination of highly mixed country ancestry (impacting validity of height phenotype) and admixture of the 1000Genomes population (impacting variability in the polygenic scores for height): African Ancestry in Southwest US (ASW; N = 66), African Caribbean in Barbados (ACB; N = 96). One population was excluded due to the absence of a single European country of origin (needed for height phenotype information used in this report): Utah residents with Northern and Western European ancestry (CEU; N = 103). Details are given in Supplementary Table 1. All ethical regulations (including informed consent) were followed in the relevant studies, which provided the summary results used in this manuscript. This manuscript contains only secondary data analysis of publicly available data. No work with human participants was conducted, as determined by the Human Subjects review board at Stanford University.