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Chunk #2 — INTRODUCTION

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Microstructural abnormalities in callosal fibers and their relationship with cognitive function in schizophrenia: A tract-specific analysis study.
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Cognitive impairment is a core dysfunction of schizophrenia that is associated with functional prognosis (Green & Harvey, 2014), but much of its pathophysiology is unknown. Cognitive performance is strongly associated with communication between multiple brain regions (Fox et al., 2005). Development of CC in childhood is correlated with intelligence, processing speed, and problem‐solving ability, and is thought to play a fundamental role in cognitive functioning (Hinkley et al., 2012). However, few studies have performed detailed investigation of the relationship between microstructural abnormalities of CC and cognitive functioning in schizophrenia.