found that heritability of individual criteria (in a subset of the data used here) were between 29% (Tolerance) and 59% (Drinking more than intended) 9. Genomic data also support this variability with Palmer et al reporting a SNP-based heritability ranging from 13% (Time spent drinking) to 34% (Tolerance) 15. The variability across these estimates likely arises from ascertainment (e.g., ascertained for addiction vs. twin epidemiologic sample) and the analytic approach (e.g., using SNPs vs. family relatedness). In addition, in one study, the observed associations with ADH1B loci were also differentially attributable to Tolerance, Withdrawal, Drinking more than intended, and Time spent drinking, relative to other criteria 16.
