In the initial 500-KB region, there are ∼2604 SNVs present at >1% MAF (dbSNP132), of which 109 are classified by RegulomeDB as having a potentially functional consequence. Using an association test on 113 SNVs in the tested European and Asian populations, we are able to identify 28 SNVs in association with the disease in common between Europeans and Asians. Of these SNVs, our approach classifies three as having potential functional consequence—each of which provides an easily testable hypothesis.
