Chunk #13 — Methods — Data imputation and statistical analysis

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Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies.

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We set the study-wide genome-wide significance level at p<5×10−8 to control the experiment-wide error rate to <5%. Following the example of previous GWAS studies,15 we set the level for suggestive significance at p<5×10−6.