Standard pre-imputation quality control metrics (Marees et al. 2018) were applied in all within-sample genetic analyses including removing SNPs with minor allele frequency (MAF) <1%, call rate <95%, Hardy-Weinberg Equilibrium (HWE) p < 1e-6, and removal of participants with excess autosomal heterozygosity or homozygosity (F < −.1 or F > .1). All samples were imputed to the Haplotype Reference Consortium (HRC) reference panel (McCarthy et al. 2016). SNPs with low imputation quality (Info Score < .80) were removed prior to analysis.
