at an early stage before further symptoms arise [18, 19]. Perhaps more importantly, our previous studies have shown that gene expression in the hippocampus is particularly sensitive to the effects of acute ethanol (1.8 g/kg) [20, 21]. Others have also shown that acute ethanol (2.0 g/kg) produces brain region-specific changes in gene expression, including in the hippocampus [22]. Thus, the hippocampus is an excellent target for examining how Cd14 potentially regulates ethanol responses. Further, the examination of acute ethanol treatment may allow for the identification of mechanisms, including gene networks that are also important in the cascade of events that lead to addiction and other chronic illnesses.
