factors, diagnostic markers and therapeutic drugs. The list simply defines the membership to the underlying molecular system, but is still useful for computational analysis. Table 2.KEGG MEDICUS for disease and drug informationKEGG DISEASEKEGG DRUGURLhttp://www.genome.jp/kegg/disease/http://www.genome.jp/kegg/drug/DatabaseGene/molecule lists consisting of disease genes, environmental factors, diagnostic markers, and therapeutic drugsChemical structures and/or components of approved drugs in Japan, United States and Europe with additional information including: targets, metabolizing enzymes and drug interactionsPathway mapKEGG pathway maps for human diseases including: cancers, immune disorders, neurodegenerative diseases, circulatory diseases, metabolic disorders and infectious diseasesKEGG pathway maps for drug metabolism; KEGG pathway maps for biosynthesis of antibiotics and natural products; and KEGG DRUG structure maps for drug developmentBRITE hierarchyDisease classifications including: Pathogens and infectious diseases; Human diseases; and ICD-10 disease classificationDrug classifications including: Therapeutic category of drugs (Japan); ATC classification (WHO); TCM (Traditional Chinese Medicine) drugs in Japan; and Crude drugs in JapanRelease20082005
