loci approached significance, including SNPs at LMO1, PLCL1, KCNB2, and DDC (Kapoor et al., 2013, Pan et al., 2013). One study identified a locus on C12orf51 associated with alcohol consumption in Korean men at an extremely high level of significance (p=5.8 x 10-46) (Baik et al., 2011). Interestingly, the majority of these GWAS have not replicated the association of the ADH1B gene with MaxDrinks that was previously reported from several studies (Bierut et al., 2012, Macgregor et al., 2009) except for one (2.04 x 10-8) in the combination of COGA and SAGE samples(Kapoor et al., 2013). . Thus, in order to identify genetic influences on MaxDrinks and to establish the role of ADH1B on Maxdrinks, additional GWAS in large sample populations with high-density genotyping arrays in EAs and AAs are warranted.
