We used Ingenuity pathway analyses to determine whether there was any increased enrichment in HR-associated pathways with the contribution of our five newly identified loci. We identified 16 significantly enriched pathways at P < 1 × 10−4. Most of these pathways are related to the cardiovascular system and involve, for example, supraventricular arrhythmias, dilated cardiomyopathy and HR (Supplementary Material, Table S9).
