SMR quantifies the strength of the association between expression levels of a gene and complex traits with TSMR using the following function of the eQTL and GWAS Z-score statistics13\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$T_{\mathrm{SMR}} = \frac{{Z_{{\mathrm{eQTL}}}^2Z_{{\mathrm{GWAS}}}^2}}{{Z_{{\mathrm{eQTL}}}^2 + Z_{{\mathrm{GWAS}}}^2}}$$\end{document}TSMR=ZeQTL2ZGWAS2ZeQTL2+ZGWAS2
