Biobank array and is more prevalent in Africans (MAF = 0.01) than Europeans (MAF = 0.0007). Therefore, replication was sought in 1,437 individuals of African American-ancestry from the HRS and COGA studies. Analysis methods for replication cohorts were the same as for discovery cohorts, including methods to analyse chromosome X (Supp. Table 2). The criteria set for the replication were (i) the same direction of effect as the discovery analysis and (ii) P ≤ 0.0045 in the replication studies (Bonferroni-adjusted for eleven SNVs at α = 0.05).
