5 of the 16 (31%) confirmed or suggestive loci associated with height have let-7 binding sites, compared with 2% of the genes in the human genome (Fisher’s exact test P = 3 × 10-5). Because microRNAs can co-regulate genes involved in the same biological process, it will be interesting to test whether the other targets of let-7, or let-7 itself, are regulators of adult height.
