The allele frequencies (in controls) of the 28 SNPs that gave the most significant association with heroin addiction in the AA population (this study) and the EA population (Levran et al. 2008) are listed in Table 4. Significant differences, after correction for multiple testing (uncorrected P < 4.5E-05), between the two populations were observed for 12 SNPs. These include five SNPs in the EA study and seven SNPs in this study. Six additional SNPs, indicated in the current study, have point-wise significant difference in allele frequencies between the two populations (4.5E-05 < P < 2.3E-02). Four SNPs in this study and one SNP in the EA study have non significant differences in allele frequencies (Table 4). The allele frequencies of reference populations from HapMap (Yoruba in Ibadan, Nigeria (YRI) and Utah residents with Northern and Western European ancestry (CEU), (The International HapMap Consortium, 2003)) are listed in Table 4 for comparison. There is high similarity between the data from our populations and the HapMap data with an expected difference between the admixed AA population and the YRI population.
