the results were not statistically significant. To scrutinize potential confounders for cessation, we utilized available questionnaire data and excluded NAG-FIN individuals who either have a DSM-IV major depression disorder diagnosis or report quitting due to adverse health consequences and FINRISK individuals who have a relevant somatic diagnosis, are on disability pension, or rate their health as ‘poor’. Further, we adjusted the analyses for alcohol consumption. After these exclusions, 2946 current and 2591 former smokers remained, and the wGRS result no longer was statistically significant (OR = 1.30, 95% CI 0.95–1.78, p = 0.10). We also tested these models with the rs56113850*rs113288603 interaction term included as a covariate; in all the models the interaction term was non-significant (p>0.05) and so a more complex model was not justified.
