The genotyping in this study provides coverage of all the major genes known to be involved in the metabolism of alcohol in a large sample of European Americans. We have relatively complete, comprehensive phenotypic information covering a wide range of alcohol use, abuse, and dependence parameters available to test for genetic association. Also, several of the SNP associations we report replicate previous findings, and/or have potential, or in the case of rs1229984, proven functionality. The association between rs1229984 and both DSM-IV symptom count and max drinks satisfies multiple test corrected significance thresholds based on a Bonferroni adjustment based on the 113 independent tests. Finally, this study extends the findings to a community-based population as opposed to a sample recruited from treatment centers.
