et al., 2012; Zolezzi and Inestrosa, 2014). Cramer et al. reported that bexarotene, a retinoid X receptor agonist, stimulated the ApoE-dependent Aβ clearance through the actions of liver X receptors and peroxisome proliferator-activated nuclear receptor gamma in AD model mice (Cramer et al., 2012). As a result, cognitive deficits improved with reduced burden of Aβ plaque. However, some conflicting reports have been also documented (Fitz et al., 2013; Price et al., 2013; Tesseur et al., 2013; Veeraraghavalu et al., 2013). Further analysis and experimentation should be performed.
