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Chunk #39 — DISCUSSION

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Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression.
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Although our consortium tested many high-priority combinations of factors (see Supplemental Table S2), there remain other specific situations that we were unable to evaluate, such as limiting analyses to stress over a period shorter than five years, to financial stress,71 to persistent or recurrent depression,29, 72 or to childhood emotional abuse/neglect only.73 Using data from a diverse set of studies, most designed to address other questions, is also a limitation. However, we note that many of the participating studies, despite their diversity, have already been cited in the literature either in support of, or against, the hypothesized interaction.