CELSR3 belongs to the flamingo subfamily of non-classic cadherins, which are defined by non-interaction with catenins and seven transmembrane domains (Feng et al., 2012). The protein encoded by this gene may be involved in the regulation of contact-dependent neurite outgrowth (Chai et al., 2015). In mice, Celsr3 appears to be critical for axon pathfinding in the central nervous system, with cortico-cortical and cortico-subcortical connections defective in mutant mice (Tissir et al., 2005; Zhou et al., 2008). Moreover, the role of Celsr3 in steering motor axons innervating the dorsal hindlimb and in the anterior-posterior patterning of monoaminergic neurons has also recently been demonstrated (Chai et al., 2014; Fenstermaker et al., 2010).
