significance. In contrast, VPL ↔ S1 connectivity was significantly stronger in layer IV than in layers I, V, and VI (Fig. 4b). We then examined the inter-hemispheric cortico-cortical connections for all 68 cortical regions for each layer (i.e., between the left and right brain regions of the same area). We found that the inter-hemispheric cortico-cortical mean correlation for layer III was significantly greater than layer VI (Fig. 4c).