Another strategy is to make use of publicly available datasets, which are expanding every day. However, this does not mean we need to wait for sample sizes to double before asking questions about sex differences. The Psychiatric Genomics Consortium (PGC) currently has a sample size of greater than 400,000 subjects with phenotypic information covering a wide range of psychiatric disorders [37]. Further, the PGC is committed to open sharing of data, and because the NIH requires datasets to be published along with manuscripts, recruiting enough individuals’ genotype information is no longer an insurmountable task, especially as data from “control” samples are growing rapidly (e.g., 1000 genomes—[38]; Precision Medicine Initiative®—[39]).
