Altogether, our previous study of DSM-IV symptoms and these recent molecular studies of DSM-IV and DSM-5 AUD underscore the need to characterize the multivariate genetic architecture of DSM-5 AUD symptoms. The present paper uses subjects of European ancestry from the Study of Addiction: Genetics and Environment Consortium to characterize the genetic architecture of the 11 DSM-5 AUD symptoms. It builds upon our previous report by comparing several models that test the assumption of genetic homogeneity across AUD symptoms. The goals of this study were to:
