CJ performed data manipulation, analysis and participated in the interpretation of the results. TD participated in DNA pool preparation, data acquisition, data analysis and manuscript preparation. QRL and PWZ participated in probe synthesis and data acquisition. DW performed the DNA and DNA pool preparation and participated in data acquisition. CYL participated in data analysis. JA participated in conception of the study and worked with the ECA study. YD helped to identify participants with specific clinical characteristics. WE participated in the conception of the study, study design and funding, and interpretation of the results. GRU conceived the study, participated in study design, data analysis and drafted and edited the manuscript. All authors read and approved the final manuscript.
