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Chunk #38 — METHODS — Post-hoc analyses of European ancestry GWAS results — Biological Characterization — Fine-mapping with SusieR.

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Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders.
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We fine-mapped the association statistics of the four phenotypes (addiction-rf, PAU-specific, PTU-specific, CUD-specific; OUD-specific only had one significant loci, and that loci has known mechanism of effect) that had more than 1 genome-wide significant SNP in a 1 MB region around the lead SNP to determine the 95% credible set using susieR61 with at most 10 causal variants (this analysis reduces the total number of SNPs at a lead genome-wide signal to those that can credibly be considered as causal SNPs). The credible set reports include the likelihood of being a causal variant; the marginal posterior inclusion probability (PIP) ranges from 0 to 1, with values closer to 1 being most likely causal.