gene ends (P = 9.22×10−47 by Wilcoxon Rank Sum test; Fig. S3b). Computational prediction of nucleosome density from DNA sequence [28] showed a significant correlation between nucleosome position and H3K9 acetylation levels observed by microarray (R = 0.2, P = 2.2×10−16 by Pearson's correlation; Fig. S4). These observations of lower absolute levels of DNA methylation with CpG islands and higher levels of transcription within exons associated with lower DNA methylation and H3K9 acetylation levels in 5′ gene ends indicate that our epigenetic and transcription microarray results conform to previously published data in other genomic loci.
