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Chunk #15 — MATERIALS AND METHODS — Phase‐amplitude coupling calculation

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Effects on resting-state EEG phase-amplitude coupling in insomnia disorder patients following 1 Hz left dorsolateral prefrontal cortex rTMS.
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To improve measurement robustness and sensitivity and reduce spurious coupling (Aru et al., 2015), the PAC value was normalized by the z‐score relative to the distribution of surrogate values, which was derived from random‐point amplitude time block‐swapping (200 iterations). We calculated the PAC value every 8 s, averaged the PAC values (approximately 40 epochs), and considered the average as the final PAC value. PAC was calculated using the TensorPac toolbox (Combrisson et al., 2020).