A binary measure representing whether at least one of the biological parents of the respondent had a history of DSM-5 AUD was used. Various sources of information were used to derive family history (e.g., parental interview, respondent report; see (Bucholz et al., 2017; McCutcheon et al., 2017) for details). Of the analytic sample, 1,656 individuals did not have a report on family history, and 485 individuals had a missing report on one parent while the other parent was confirmed to be family history negative. Thus, family history was not included as a covariate in all analyses and for analyses including family history (e.g., PRS*family history), the sample size was smaller (N = 5,075).
