After acquisition of high-resolution anatomical images, functional images were acquired with scan parameters as follows: repetition time 2.5 seconds, echo time 24 miliseconds, voxel size 3.5mm isotropic, interleaved slice acquisition, head-first prone slice encoding (to reduce susceptibility artifact), no skip, 35 coronal slices starting at the frontal pole and covering the entire brain, flip angle=90°. A total of 240 frames were collected over a 10:05 minute scan and the first two frames were discarded for magnetic field equilibration. Using SPM2 (http://www.fil.ion.ucl.ac.uk/spm), data were realigned to correct for motion, normalized into Talairach space, resliced, and smoothed with a 6mm Gaussian kernel. Data were also slice time corrected. Translational motion of all subjects was less than 2mm in all 3 dimensions except two control subjects who moved 2.5mm in one dimension. Mean displacement in the x-, y-, and z- dimensions were 0.01±0.18mm, 0.46±0.23mm, 0.11±0.55mm for healthy controls, 0.01±0.35mm, 0.38±0.30mm, 0.09±0.44mm for bipolar disorder, and 0.22±0.22mm, 0.36±0.23mm, 0.14±0.61mm for schizophrenia, respectively. Mean pitch, roll, and yaw were 0.002±0.007°, -0.001±0.005°, 0.002±0.003° for healthy controls, -0.002±0.012°, -0.002±0.006°, 0.001±0.006° for bipolar disorder, -0.002±0.009°, 0.000±0.008°, 0.005±0.004° for schizophrenia, respectively. There were no between-group differences in these six measures.
