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Chunk #21 — 2. METHODS — 2.3 Statistical Analyses — Common Pathway model

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Genetic etiology of the common liability to drug dependence: evidence of common and specific mechanisms for DSM-IV dependence symptoms.
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Model” (Neale et al., 2003), that assumes that there are no sex-specific additive genetic factors but that the relative contribution of genetic and environmental factors differs between men and women (Model II). Finally, we tested a model that posits that there are no sex-specific additive genetic factors, and that the magnitude of genetic and environmental effects are the same across sexes (Model III; otherwise known as a “Scalar Effects Sex-Limitation Model” (Neale et al., 2003). All three models were fitted to the data to test for both qualitative and quantitative gender differences. After establishing the best-fitting sex-limitation model, we then proceeded to test specific parameters.