We conducted bulk RNA-seq analysis in human microglia generated from iPSCs (n = 9, four high-PRS, and five low-PRS, both sexes; table S1) (32). We first compared the expression levels with a publicly available single-cell RNA-seq dataset of adult human brain cells (45). The iPSC-derived microglia and adult human microglial cells show very similar transcriptomic profiles (fig. S4A), indicating the appropriate differentiation of our human microglia.
