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Chunk #6 — Volume Conduction and Source Localization: Putative Midline Generators of Novelty P3

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Novelty P3 reductions in depression: characterization using principal components analysis (PCA) of current source density (CSD) waveforms.
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methodologies actually introduces an electrophysiological paradox: Unless the generator is restricted to the banks of the cingulate sulcus, rather than the cingulate gyrus itself, the equivalent dipole should be tangential to the midline scalp. In this regard, it is notable that a tangential generator is consistent with published CSD maps of novelty P3, in which a midline source may be coupled with lateral sinks (cf. Figures 5 and 8 of Friedman et al., 2001).