If we are convinced of the value of genetic research (more specifically, common variant discovery and mechanistic probing), but also cognizant of polygenicity, statistical power, and the inherent limitations of nosological boundaries (e.g., heterogeneity and comorbidity) and prior mechanistic knowledge, how might genetic research be leveraged to inform clinical psychology? Polygenic risk scores (PRS) may usefully contribute to the identification of disorder-related risk factors, our understanding of comorbidity, and begin to provide insights into the developmental trajectory of psychiatric phenotypes as well as their course, treatment, correlates, and underlying pathophysiologies.
