As in primates, the rodent PFC is located in the anterior pole of the frontal cortex and is loosely defined as the ACC, the medial PFC, and the OFC, as well as portions of the agranular insular cortex. The rodent medial PFC is subdivided into a dorsally located prelimbic mPFC (PrL-mPFC) and ventrally located infralimbic mPFC (IfL-mPFC) subregion. The OFC is also subdivided into the medial, ventral, lateral, and dorsolateral orbitofrontal regions. The connectivity of the rodent PFC has common features with that of primates, including a dorsal-to-ventral gradient of projection patterns. For example, the PrL-mPFC sends dense projections to the dorsal striatum that transitions to the ventral stratum (nucleus accumbens) as one moves ventrally through the IfL-mPFC to the OFC.
