The current study combines data from the two unpublished OCD GWASs described above and includes additional cohorts (~9,000 cases). This results in the largest and most well-powered GWAS of OCD to date, with a ~20-fold increase of OCD cases compared to the previously published OCD GWASs10. Based on the results from the meta-analysis, we conducted secondary analyses, including positional and functional fine-mapping of SNPs and genes, structural equation modeling to examine possible genetic differences in sample ascertainment across cohorts, protein and transcriptome-wide association analyses, single-cell enrichment, and genetic correlations with other traits (Supplementary Fig. 1). Our results provide more detailed insight into the genetic underpinnings and biology of OCD.
