The inclusion of the Genetics Portal evidence in the Open Targets Platform supersedes the previous GWAS catalog evidence, removed in release 20.02 (Figure 3, Supplementary Figure S1). The inclusion of a more stringent GWAS p-value cutoff (5e–8 instead of 1e–5) removed 69 298 non-significant GWAS catalog evidence data points. Overall, the Genetics Portal provides a cutting-edge framework to obtain the most up-to-date GWAS evidence for complex or common diseases or phenotypes.
