of cue-reactivity have been reported as a function of alcohol use (Vollstadt-Klein et al., 2010). Conversely, the different pattern of mesolimbic activation found in previous studies by Filbey et al. (2008a, b) may reflect differences in statistical power as well as the statistical approach. The studies by Filbey et al. primarily focused on region of interest (ROI) analyses as compared to whole-brain analyses, which are more statistically stringent due, in part, to the multiple comparisons correction applied. Further, we note that the exploratory whole brain analysis reported in Filbey et al. (2008a) did not find significant mesolimbic activation for the alcohol versus control taste contrast. These methodological differences are likely to account, at least in part, for the discrepancy in the findings while also suggesting that the results may be more congruent at the whole-brain level of analysis.
