Notably, POU showed positive genetic correlations with OUD as measured by the Million Veteran Program (MVP, rg = 0.64, p = 9.97E−09, European), with opioid dependence versus unexposed controls (European) as measured by the Psychiatric Genomics Consortium (PGC, rg = 0.80, p = 3.24E−04; opioid dependence versus opioid exposed controls showed no significant heritability and therefore could not be tested), and with opioid medication use (rg = 0.46, p = 2.25E−12) in participants from UKB.
