phenotypes have been shown in Israeli Jews (Hasin et al., 2002; Neumark et al., 1998), including association with maximum drinks consumed in a 24-hour period (“Maxdrinks”) and AUD severity in recent work in a large household sample (Meyers et al., 2013). This large sample of Jewish Israelis presents an important opportunity to investigate whether the association of ADH1B and alcohol phenotypes is moderated by environmental factors.